Non-Interventional, controlled, open-label, prospective, multicenter, observation registry study. Investigation of clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with acute ischemic stroke. All patients receive acute stoke care according to local treatment standards, not amended or influenced by the study. The control group is the patients not treated with Cerebrolysin. Approximately 50 centers are participating. Approximately 2000 patients will be enrolled in the study.